Hi Jeremy
Bryan is quite right - always back up before doing anything potentially destructive to your system. And always backup anyway. And then backup some more...
But to add to that, you will find that there is no Uninstall application icon with Vectorworks,it is simply a case of dragging the folder from the Applications folder to the Trash. This does not remove your resource browser favourite links or any preference settings, as these are stored under Library/Application Support/Vectorworks/2010.
If you have made any folders for your own symbols etc, make sure they are NOT saved in Applications or you will lose them.
But I guess, even before doing this, is to ask has the crashing just started?
Has something changed on the Mac? For example, have you updated the operating system to Lion?
Do you have the latest service pack for 2010?
Do feel free to give us a call in the office if you are still having problems.
All the best and hope you are well!