Yes I do have that set to save. All I was doing is adding annotation to the 4 veiwport elevations on a sheet. Just once in while it will lose the render info to all 4 viewports, not just the one I working on. I don't know why it keeps it sometimes and loses it other times. I under stand if I change anything on the design layer the viewports will go back to wire. It seems with everything set to keep the cashe I should be able to do anything I want on annotation without losing the render cashe.
Thanks for trying Jonathan,