I just encountered a similar issue with a mostly greyed-out, non-selectable drawing. Layers was set to show/snap/modify others as was class, but most of the objects on all layers were greyed out and not selectable, although the snap was working. I didn't make any changes to the drawing beyond adding a notes box when it happened. So, I did some nosing around on this forum and others and started exploring my settings. It turns out the "none" class had mysteriously been made non-visible. I changed it to visible and the problem was solved. Now, I need to figure out how the switch happened, but I'm thankful I'm not redrawing a set design right now.