I am having a similar problem, sometimes when files are saved they become corrupted, rendering them unopenable. The error message when we try to reopen is:
"Unexpected end of file encountered during file read operation (failure on attempt to open file)"
the file size is reduced down to 4kb, the problem is also apparent for the backup copies.
I was advised to Download 12.5.1 to resolve it, however its just happened again.
We have lost a considerablem amount of work because of this so far.
Thanks
Ian