Hi Jeremy - Thanks, but I'm not a Mac, PC. I don't have to change permissions when swapping from 2017 all the way to 2020. But 2021 doesn't recognize it even though I have specifically instructed it to in the mouse software (Which I don't need to do for other VW versions). I don't think the OS is "blocking it" as it works for all other programs and the basic functions work correctly within 2021, just not my programmed buttons. Might try a different Mouse 🙂